Xadago is a medicine whose active substance is safinamide. This drug s It is used as a complementary therapy for the treatment of Parkinson’s disease, being used for episodes of difficulty in movement, known as off episodes .
Xadago works by increasing the level of the neurotransmitter dopamine in the brain. Dopamine is a substance that is involved in the control of movement. In Parkinson’s patients, dopamine is at lower levels than in unaffected people.
How does Xadago work?
Safinamide reversibly and specifically inhibits MAO-B. Although Xadago also has other mechanisms of action such as the following:
It is a calcium channel antagonist.
Inhibits dopamine reuptake.
It works as an antagonist in the release of glutamate.
This drug is the only one with a dual mechanism of action for Parkinson’s disease. For this reason, it influences the control of symptoms and motor alterations when the pathology is in the middle or advanced stages. It is in those periods that there are fluctuations of movement.
Currently there are other MAO-B inhibitors for the treatment of Parkinson’s, however, they do not have the other mechanisms of action that safinamide possesses.
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